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Immunization
New immunization research from S. Agrawal et al outlined
March 26th, 2008
According to a study from the United States, "TLRs (Toll-like receptors) are a family of innate immune receptors that induce protective immune responses against infections. Single-stranded viral RNA and bacterial DNA containing unmethylated Ill motifs are the ligands for TLR7 and TLR8 and 9 respectively." "We have carried out extensive structure-activity relationship studies of DNA- and RNA-based compounds to elucidate the impact of nucleotide motifs and structures on these TLR-mediated immune responses. These studies have led us to design novel DNA- and RNA-based compounds, which act as potent agonists of TLR9 and TLR7 and 8 respectively. These novel synthetic agonists...
Source: Vaccine Weekly (2008-03-26)
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