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Immunization
Research on immunization discussed by scientists at University of Utah, Medical Department
March 26th, 2008
"Cathelicidin production by human myeloid cells stimulated through toll-like receptor (TLR) 2/1, the migration of human CD8(+) T cells to inflamed skin sites, and the ability of murine dendritic cells (DCs) to migrate from skin sites of vaccination to mucosal lymphoid organs all occur via calcitriol-dependent mechanisms. Herein, we report that murine DCs exposed to TLR3/TLR4 ligands upregulate their expression of lot-hydroxylase, the enzyme that converts circulating 25(OH)D-3 to calcitriol, the active form of vitamin D3," investigators in the United States report. "TLR3/TLR4 ligands injected subcutaneously affect DC migration in vivo, allowing their trafficking to both...
Source: Vaccine Weekly (2008-03-26)
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