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Cancer Vaccines
Research conducted at Army has provided new information about cancer vaccines
March 26th, 2008
According to recent research published in the journal Clinical Cancer Research, "E75 is an immunogenic peptide from the HER2/neu protein, which is overexpressed in many breast cancer patients. We have conducted two overlapping E75 vaccine trials to prevent recurrence in node-positive (NP) and node-negative (NN) breast cancer patients." "E75 (HER2/neu 369-377) + granulocyte macrophage colony-stimulating factor was given intradermally to previously treated, disease-free NP breast cancer patients in a dose escalation safety trial and to NN breast cancer patients in a dose optimization study. Local and systemic toxicity was monitored. Immunologic responses were...
Source: Vaccine Weekly (2008-03-26)
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