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Cancer Vaccines
Research from University of California broadens understanding of cancer vaccines
March 26th, 2008
"Despite recent advances in cancer immunotherapy, cellular mechanisms controlling expression of tumor-associated antigens are poorly understood. Mutations in cancer cells, such as loss of PTEN, may increase expression of: tumor-associated antigens," investigators in the United States report. "The authors investigated the relationship between PTEN status and the expression of a glioma-associated antigen, adenosine diphosphate-ribosylation factor 4-like (ARF4L) protein. Human glioma cell lines with confirmed PTEN status were examined by Northern blot analysis and quantitative polymerase chain reaction. Western blot analysis was used to measure ARF4L, protein levels across...
Source: Vaccine Weekly (2008-03-26)
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