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Allergies
New allergies research has been reported by scientists at Johann Wolfgang Goethe University
March 26th, 2008
"Particle-mediated epidermal delivery (PMED) of allergen genes efficiently prevents systemic sensitization and suppresses specific immunoglobulin E synthesis. We investigated in a mouse model of allergic airway disease the effect of PMED on the elicitation of local inflammatory reactions in the lung," researchers in Mainz, Germany report. "BALB/c mice were biolistically transfected with plasmids encoding beta-galactosidase (beta Gal) as model allergen under control of the DC-targeting fascin promoter and the ubiquitously active cytomegalovirus promoter, respectively. Mice were challenged intranasally with beta Gal-protein with or without intermediate sensitization with...
Source: Vaccine Weekly (2008-03-26)
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