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Vaccine Weekly

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Falciparum Malaria



Reports from S. Garg and co-researchers add new data to research in falciparum malaria



March 26th, 2008

According to recent research published in the Malaria Journal, "The Plasmodium falciparum apical membrane antigen I (AMAI) is a leading malaria vaccine candidate antigen. The complete AMAI protein is comprised of three domains where domain I exhibits high sequence polymorphism and is thus named as the hyper-variable region (HVR)."

"The present study describes the extent of genetic polymorphism and natural selection at domain I of the amal gene among Indian P. falciparum isolates. The part of the AMAI gene covering domain I was PCR amplified and sequenced from 157 P. falciparum isolates collected from five different geographical regions of India. Statistical and...


Source: Vaccine Weekly (2008-03-26)

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