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DNA Vaccines
Studies from Kyushu University describe new findings in DNA vaccines
March 26th, 2008
According to recent research from Fukuoka, Japan, "We have developed a DNA vaccine encoding a fusion protein of ubiquitin (Ub) and target proteins at the N-terminus for effective induction of antigen-specific CD8(+) T cells. A series of expression plasmids encoding a model antigen, ovalbumin (OVA), fused with mutated Ub. was constructed." "Western blotting analyses using COS7 cells transfected with these plasmids revealed that there were three types of amino acid causing different bindin capacities between Ub and OVA. Natural Ub with a C-terminal glycine readily dissociated from OVA; on the other hand, artificially mutated Ub, the C-terminal amino acid of which had been...
Source: Vaccine Weekly (2008-03-26)
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