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Fusion Proteins
Investigators at Lund University publish new data on fusion proteins
March 26th, 2008
According to a study from Lund, Sweden, "Identification of antigens that elicit protective immunity is essential for effective vaccine development. We investigated the related surface proteins of group B Streptococcus, Rib and a, as potential vaccine candidates." "Paradoxically, nonimmunodominant regions proved to be of particular interest as vaccine components. Mouse antibodies elicited by Rib and oc were directed almost exclusively against the C-terminal repeats and not against the N-terminal regions. However, a fusion protein derived from the nonimmunodominant N-terminal regions of Rib and oc was much more immunogenic than one derived from the repeats and was...
Source: Vaccine Weekly (2008-03-26)
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