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Vaccine Weekly

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Respiratory Disease



Studies in the area of respiratory disease reported from University of Queensland



April 2nd, 2008

"Recently identified human metapneumovirus (hMPV) is an important respiratory pathogen in children and adults worldwide. Little is known about cytotoxic T lymphocyte (CTL) responses that may control hMPV infection in humans," scientists in Australia report.

"To address this, we evaluated major histocompatibility complex (MHC) class I T cell immunity in 7 patients with previous hMPV respiratory disease. CTL responses were evident in most patients and to most proteins of hMPV. Individual patients had responses to at least 2 hMPV proteins (particularly the M protein) and had multiallele responses. In addition, we identified 9 CTL epitopes that are presented by human...


Source: Vaccine Weekly (2008-04-02)

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