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Cancer Vaccines
Scientists at Leiden University release new data on cancer vaccines
April 2nd, 2008
"Tumorigenesis is frequently associated with mutation and overexpression of p53, which makes it an attractive target antigen for T cell-mediated immunotherapy of cancer. However, the magnitude and breadth of the p53-specific T-cell repertoire may be restricted due to the ubiquitous expression of wild-type p53 in normal somatic tissues," scientists writing in the journal Cancer Research report. "In view of the importance of the CD4+ T-helper cell responses in effective antitumor immunity, we have analyzed and compared the p53-specific reactivity of this T cell subset in p53+/+ and p53-/-C57B1/6 mice. This response was found to be directed against the same three...
Source: Vaccine Weekly (2008-04-02)
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