DNA Vaccines

Researchers at University of Pennsylvania, Medical Department target DNA vaccines

Published in Vaccine Weekly, April 2nd, 2008

According to a study from the United States, "In an effort to improve DNA vaccine immune potency electroporation has emerged as a method of delivery of plasmids to target tissues. However, few studies have examined the use of this technology to deliver plasmid vaccines to the skin."

"Here we studied the effect of electroporation on DNA vaccine potency and gene delivery using skin as a target tissue in larger animal species. Using a pig model, we determined that high plasmid concentrations resulted in improved gene expression for plasmid GFP delivered by the intradermal/subcutaneous (ID/SQ) route. In a macaque model, we observed higher cellular and humoral. responses to...

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Source: Vaccine Weekly (2008-04-02)

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