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Vaccine Weekly

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Genetics & Genomics



Findings from University of Oxford provide new insights into genetics & genomics



April 2nd, 2008

"Genetic variation at classical HLA alleles is a crucial determinant of transplant success and susceptibility to a large number of infectious and autoimmune diseases. However, large-scale studies involving classical type I and type II HLA alleles might be limited by the cost of allele-typing technologies," scientists in Oxford, the United Kingdom report.

"Although recent studies have shown that some common HLA alleles can be tagged with small numbers of markers, 1,2 SNP-based tagging does not offer a complete solution to predicting HLA alleles. We have developed a new statistical methodology to use SNP variation within the region to predict alleles at key class I...


Source: Vaccine Weekly (2008-04-02)

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