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Vaccine Weekly

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Leishmaniasis



Findings from I. Ramos and co-authors provide new insights into leishmaniasis



April 2nd, 2008

According to recent research from Madrid, Spain, "Leishmaniasis caused by Leishmania infantum is a severe endemic disease in the Mediterranean basin, being domestic dogs the main reservoir of the disease that plays a key role in the transmission to humans. Studies on vaccines against canine leishmaniasis, aimed to modify the T cell repertoire, have advanced in recent years."

"LACK vaccination assays, using protein or DNA vectors, show protection against cutaneous L. major infections by redirecting the early IL-4 responses to a protective Th1 response. The aim of this study was to define the effectiveness and type of immune response in a canine visceral leishmaniasis...


Source: Vaccine Weekly (2008-04-02)

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