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Microparticle
Research from Complutense University provide new insights into microparticle
April 2nd, 2008
" Biodegradable microparticles, in particular poly(lactide-co-glycolide) (PLGA), have been shown as potential delivery vehicles for intranasal (i.n.) vaccines in animal models. Objectives To evaluate whether i.n. administration of PLGA microparticles containing a peptide with the major T cell epitope of Ole e 1, the main allergen of olive pollen, prevented mice from allergic sensitization to the whole protein," investigators in Madrid, Spain report. " Peptide-PLGA microparticles were prepared by a solvent evaporation double emulsion method. Microparticles in a size range of 0.8 mu m were evaluated for peptide loading and in vitro antigen release. Stability and...
Source: Vaccine Weekly (2008-04-02)
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