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Herpesvirus
Research conducted at University of California has updated our knowledge about herpesvirus
April 9th, 2008
According to a study from the United States, "Evidence obtained from both animal models and humans suggests that T cells specific for HSV-1 and HSV-2 glycoprotein D (gD) contribute to protective immunity against herpes infection. However, knowledge of gD-specific human T cell responses is limited to CD4(+) T cell epitopes, with no CD8(+) T cell epitopes identified to date." "In this study, we screened the HSV-1 gD amino acid sequence for HLA-A*0201 -restricted epitopes using several predictive computational algorithms and identified 10 high probability CD8(+) T cell epitopes. Synthetic peptides corresponding to four of these epitopes, each nine to 10 amino acids in...
Source: Vaccine Weekly (2008-04-09)
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