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Vaccines
Researchers at Medical College of Wisconsin, Medical College release new data on vaccines
April 9th, 2008
"The botulinum neurotoxins (BoNT) are the most toxic proteins for humans and designated ''Category A Select Agents.'' The current vaccine against botulism is in limited supply, and there is a need to develop new vaccine strategies. A recombinant BoNT/A toxoid was produced in Clostridium botulinum that contained a double amino acid substitution, R363A Y365F (termed BoNT/A(RYM))," scientists writing in the journal Infection and Immunity report. "BoNT/A(RYM) was noncatalytic for SNAP25 and nontoxic for mice. Immunization with BoNT/A(RYM) protected mice from challenge at levels that were similar to chemically inactivated BoNT/A toxoid. BoNT/A(RYM) elicited an immune...
Source: Vaccine Weekly (2008-04-09)
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