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HIV/AIDS
Study data from J.S. Gach and co-authors update knowledge of HIV/AIDS
April 9th, 2008
"Anti-idiotypic antibody (Ab2) 3H6 is directed against the human monoclonal antibody 2175, which is one of a few neutralising antibodies against HIV-1. Since the binding epitope of 2175 is cryptic and no neutralising immune response could be elicited by several potential vaccines comprising this region, Ab2/3H6 represents a potent vaccine candidate for active immunisation," scientists in Vienna, Austria report. "Here we describe the molecular features of Ab2/3H6 after changing the antigen binding specificity by single point mutations in the complementarity-determining region 3 of the Ab2/3H6 heavy chain. The resulting Ab2/3H6 mutants were compared in several...
Source: Vaccine Weekly (2008-04-09)
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