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Mathematical Modeling
Research from McMaster University provide new insights into mathematical modeling
April 9th, 2008
According to recent research published in the journal Bulletin of Mathematical Biology, "Poliomyelitis vaccination via live Oral Polio Vaccine (OPV) suffers from the inherent problem of reversion: the vaccine may, upon replication in the human gut, mutate back to virulence and transmissibility resulting in circulating vaccine derived polio viruses (cVDPVs). We formulate a general mathematical model to assess the impact of cVDPVs on prospects for polio eradication." "We find that for OPV coverage levels below a certain threshold, cVDPVs have a small impact in comparison to the expected endemic level of the disease in the absence of reversion. Above this threshold,...
Source: Vaccine Weekly (2008-04-09)
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