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Vaccine Weekly

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Vaccine



Recent findings from Tsinghua University highlight research in vaccine



April 9th, 2008

"Previous studies have found the close correlation between epitope density and epitope-specific response, which have shown that high epitope density in a single recombinant protein molecule significantly enhances the humoral response and protective immunity. However, it has not been determined whether this kind of high epitope density could also significantly influence T cell response," scientists in Beijing, People's Republic of China report.

"Based on this, a series of recombinant DNA and proteins were designed and prepared. Each molecule consists of various copy numbers of the V3 CTL epitope on HIV-1 gp120 (one, two, four and eight copies). Our results show clearly...


Source: Vaccine Weekly (2008-04-09)

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