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Cancer Vaccines
Research on cancer vaccines detailed by scientists at Scripps Research Institute, Department of Immunology
April 9th, 2008
Data detailed in 'A Legumain-based minigene vaccine targets the tumor stroma and suppresses breast cancer growth and angiogenesis' have been presented. "Tumor associated macrophages (TAMs) are well known to play a very important role in tumor angiogenesis and metastasis. The suppression of TAMs in the tumor-microenvironment (TME) provides a novel strategy to inhibit tumor growth and dissemination by remodeling the tumor's stroma," scientists in the United States report. "Here, we tested our hypothesis that suppression of TAMs can be achieved in syngeneic BALB/c mice with oral minigene vaccines against murine MHC class I antigen epitopes of Legumain, an asparaginyl...
Source: Vaccine Weekly (2008-04-09)
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