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Falciparum Malaria
New falciparum malaria research from National University outlined
April 9th, 2008
"Plasmodium falciparum rhoptry-associated membrane antigen (RAMA) peptides used in normal red blood cell (RBC) binding assays revealed that peptides 33426 ((79)NINILSSVHRKGRILYDSF(97)) and 33460 ((777)HKKREKSISPHSYQKVSTKVQ(797)) bound with high activity, presenting nanomolar affinity constants," investigators in Bogota, Colombia report. "Such high binding activity peptides (HABPs) displayed helicoid and random coil structures as determined by circular dichroism. HABPs inhibited P. falciparum in vitro invasion of normal RBC by up to 61% (depending on concentration), suggesting that some RAMA protein regions could be involved in P. falciparum invasion of RBC," wrote C.G....
Source: Vaccine Weekly (2008-04-09)
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