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Foot and Mouth Disease
Study results from Nanjing University broaden understanding of foot and mouth disease
April 9th, 2008
"To optimize previous candidate DNA vaccine, a cis-expression plasmid DNA encoding two genes, human IL-2 and multiple-epitopes genes of foot-and-mouth disease virus (FMDV) was constructed with internal ribosome entry site (IRES) from encephalomyocarditis virus (EMCV) and intramuscularly inoculated into mice at 1-week interval. Specific antibodies in serum and cytokines (IL-2, IL-4 and IFN-gamma) from splenocytes were detected by indirect ELISA," investigators in Nanjing, People's Republic of China report. "Splenocytes proliferation rate was determined by a standard 3-(4,5-dimethylthiazol-2-yl) 2,5-diphenyltetrazolium bromide (MTT) method. The results showed that higher...
Source: Vaccine Weekly (2008-04-09)
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