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Immunology
Scientists at University of Iowa, Department of Microbiology report research in immunology
April 16th, 2008
New research, 'TLR7 and CD40 cooperate in IL-6 production via enhanced JNK and AP-1 activation,' is the subject of a report. "During vaccination or infection, adaptive and innate immune receptors of B cells are engaged by microbial antigens/ligands. A better understanding of how innate and adaptive signaling pathways interact could enlighten B lymphocyte biology as well as aid immunotherapy strategies and vaccine design," investigators in the United States report. "To address this goal, we examined the effects of TLR stimulation on BCR and CD40-induced B cell activation. Synergistic production of IL-6 was observed in both human and mouse primary B cells stimulated...
Source: Vaccine Weekly (2008-04-16)
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