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Graves Disease Vaccines
Research from Chiba University, Department of Pediatrics has provided new information about Graves disease vaccines
April 23rd, 2008
New research, 'Enhancement of experimental Graves' disease by intranasal administration of a T cell epitope of the thyrotropin receptor,' is the subject of a report. "We previously showed that immunization of mice with murine fibroblasts transfected with the thyrotropin receptor (TSHR) and a murine major histocompatibility complex (MHC) class II molecule induces immune thyroid disease with the humoral and histological features of human Graves' disease in about 20% of mice. In this model, based on the proliferative response of T cells from hyperthyroid mice to a panel of overlapping TSHR peptides, we now demonstrate that TSHR 121-140 peptide contains an immunodominant T cell epitope,"...
Source: Vaccine Weekly (2008-04-23)
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