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Immunization
University of Oxford, Wellcome Trust Center for Human Genetics details research in immunization
April 23rd, 2008
Current study results from the report, 'Single-dose immunogenicity and protective efficacy of simian adenoviral vectors against Plasmodium berghei,' have been published. "Simian adenoviral vectors (SAd) offer an attractive alternative to standard human adenovirus serotype 5 (AdH5) subunit vaccination, due to pre-existing immunity affecting vaccine performance. We have used a mouse model of liver-stage malaria to test the efficiency of three chimpanzee-origin adenoviral vectors, AdC6, AdC7 and AdC9 containing ME.TRAP as an insert," scientists in Oxford, the United Kingdom report. "AdC7 and AdC9 elicited strong immunogenicity (approximately 20% of CD8(+) T cells in...
Source: Vaccine Weekly (2008-04-23)
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