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Immunotherapy
Reports outline immunotherapy study results from Catholic University of Korea, Department of Microbiology
April 23rd, 2008
Investigators publish new data in the report 'A membrane-bound form of IL-4 enhances proliferation and antigen presentation of CD40-activated human B cells.' "CD40-activated B (CD40-B) cells might be an attractive source of autologous antigen-presenting cells (APCs) for immunotherapy due to the ability to obtain them from peripheral blood and expand them in vitro. However, soluble IL-4 (sIL-4) in B-cell culture may not represent the 'immunological synapse' between B and CD4+ T cells," scientists writing in the journal Immunology Letters report. "In this study, the K562 cell line, which expresses CD40L and membrane-bound IL-4 (mbIL-4), could induce higher B-cell...
Source: Vaccine Weekly (2008-04-23)
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