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HIV/AIDS
Research on HIV/AIDS discussed by scientists at Rockefeller University
April 30th, 2008
"The rapid spread of HIV-1 underscores the urgent need to develop an effective vaccine. Using modified vaccinia Ankara (MVA) as a vector, we designed and constructed a multigenic candidate vaccine against a recombinant C/B' subtype of HIV-1 that is dominant in southwest China," scientists in the United States report. "Five HIV-1 genes (gag, pol, Delta V2env, tat, and nef) were introduced into 2 separate regions of the MVA genome using modified single- and dual-promoter insertion vectors. Recombinant MVA was selected by immunofluorescence double-staining and foci purification. The end product is a single recombinant MVA, termed ADMVA, that expresses HIV-1 Delta V2Env and...
Source: Vaccine Weekly (2008-04-30)
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