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Vaccine Weekly

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Simian Immunodeficiency Virus



Researchers from University of Wisconsin report recent findings in simian immunodeficiency virus



April 30th, 2008

According to a study from the United States, "Certain major histocompatibility complex (MHC) class I alleles are strongly associated with control of human immunodeficiency virus and simian immunodeficiency virus (SIV). CD8(+) T cells specific for epitopes restricted by these molecules may be particularly effective."

"Understanding how CD8(+) T cells contribute to control of viral replication should yield important insights for vaccine design. We have recently identified an Indian rhesus macaque MHC class I allele, Mamu-B*08, associated with elite control and low plasma viremia after infection with the pathogenic isolate SIVmac239. Here, we infected four...


Source: Vaccine Weekly (2008-04-30)

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