Cancer Vaccines

Researchers from University of Tokyo report on findings in cancer vaccines

Published in Vaccine Weekly, May 7th, 2008

According to recent research from Hongo, Japan, "Vaccines targeting tumour angiogenesis were recently shown to inhibit tumour growth in animal models. However, there is still a lack of information about the clinical utility of anti-angiogenic vaccination."

"Therefore, here, we aimed to test the clinical effects of a vaccine using glutaraldehyde-fixed human umbilical vein endothelial cells (HUVECs). Six patients with recurrent malignant brain tumours and three patients with metastatic colorectal cancer received intradermal injections of 5 x 10(7) HUVECs/dose (in total 230 vaccinations). ELISA and flow cytometry revealed immunoglobulin response against HUVECs' membrane...

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Source: Vaccine Weekly (2008-05-07)

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