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Immunization
New findings from University of Saarland in the area of immunization published
May 7th, 2008
According to a study from Homburg, Germany, "Protein-based immunogens are usually poor inducers of CD8(+) T cells. To enhance the induction of CD8+ T cells, one approach is the use of protein immunogens coupled to protein transduction domains (PTDs)." "These are small cationic peptide sequences that significantly enhance the uptake of fused proteins into dendritic cells (DC) and then mediate their presentation in the context of major histocompatibility complex class I (MHC-I) and MHC-II molecules. One drawback of this system is the high concentrations of PTD-fusion proteins required. Here, we show that proteins fused to the human cytomegalovirus tegument protein pp65...
Source: Vaccine Weekly (2008-05-07)
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