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Vaccine Weekly

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Stem Cell Research



Researchers at University of Rochester, David H. Smith Center for Vaccine Biology and Immunology have published new data on stem cell research



May 7th, 2008

Research findings, 'E2F4 modulates differentiation and gene expression in hematopoietic progenitor cells during commitment to the lymphoid lineage,' are discussed in a new report. "The E2F4 protein is involved in gene repression and cell cycle exit, and also has poorly understood effects in differentiation. We analyzed the impact of E2F4 deficiency on early steps in mouse hematopoietic development, and found defects in early hematopoietic progenitor cells that were propagated through common lymphoid precursors to the B and T lineages," scientists in the United States report.

"In contrast, the defects in erythromyeloid precursor cells were self-correcting over time. This...


Source: Vaccine Weekly (2008-05-07)

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