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Immunization
Researchers at Army target vaccines
May 14th, 2008
"Development of a subunit vaccine for shigellosis requires identification of protective antigens and delivering these antigens in a manner that stimulates immunity comparable to that induced by natural infection. The Shigella invasin complex (Invaplex) vaccine is an ion -exchange- purified extract from virulent Shigella that consists of LIPS and several other proteins, including the invasins IpaB and IpaC," researchers in the United States report. "Intranasal delivery of Invaplex stimulates protective immunity in small animal models for shigellosis. To identify the active component(s) of Invaplex responsible for its immunogenicity and efficacy, size-exclusion...
Source: Vaccine Weekly (2008-05-14)
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