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Addiction Medicine
Studies from University of California describe new findings in addiction medicine
May 14th, 2008
'understanding the basic and clinical pharmacology of nicotine provides a basis for improved prevention and treatment of tobacco addiction. nicotine acts on nicotinic cholinergic receptors in the brain to release dopamine and other neurotransmitters that sustain addiction. neuroadaptation and tolerance involve changes in both nicotinic receptors and neural plasticity. nicotine addiction can occur in the context of physical dependence characterized by self-medication to modulate negative affect and/or to relieve withdrawal symptoms, as well as, in light or occasional smokers, primarily for positive reinforcement in specific situations. nicotine is metabolized primarily by CYP2A6. its...
Source: Vaccine Weekly (2008-05-14)
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