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Vaccine Weekly

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Immunization



Researchers from Ludwig-Maximilians University detail findings in immunization



May 14th, 2008

A new study, 'Delivery by cationic gelatin nanoparticles strongly increases the immunostimulatory effects of CpG oligonucleotides,' is now available. According to a study from Munich, Germany, "Cationized gelatin nanoparticles (GNPs) were used as carrier to improve delivery of immunostimulatory CpG oligonucleotides (CpG ODN) both in vitro and in vivo. Uptake of CpG ODN-loaded cationized gelatin nanoparticles (CpG-GNPs) into murine myeloid dendritic cells (DCs) and their respective immunostimulatory activity was monitored."

"In vivo, induction of cytokine secretion by CpG-GNPs was measured. For experiments on primary human cells, prototypes of the three CpG ODN classes...


Source: Vaccine Weekly (2008-05-14)

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