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Vaccine Weekly

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Clostridium



Studies in the area of clostridium reported from University of Dublin, Trinity College



May 14th, 2008

"Clostridium difficile is the leading cause of infectious antibiotic-associated diarrhoea, particularly among the elderly. Its surface-layer protein (SLP) was tested as a vaccine component in a series of immunization and challenge experiments with Golden Syrian hamsters, combined with different systemic and mucosal adjuvants," scientists writing in the journal Fems Immunology and Medical Microbiology report.

"Some regimens were also tested in a nonchallenge BALB/c mouse model, enabling closer monitoring of the immune response. None of the regimens conferred complete protection in the hamster model, and antibody stimulation was variable within regimens, and...


Source: Vaccine Weekly (2008-05-14)

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