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Vaccine Weekly

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Hepatitis B Virus



Researchers from GlaxoSmithKline detail findings in hepatitis B virus



May 14th, 2008

"A randomised, double-blind study assessing the potential of four adjuvants in combination with recombinant hepatitis B surface antigen has been conducted to evaluate humoral and cell-mediated immune responses in healthy adults after three vaccine doses at months 0, 1 and 10. Three Adjuvant Systems (AS) contained 3-O-desacyl-4'-monophosphoryl lipid A (MPL) and QS21, formulated either with an oil-in-water emulsion (AS02B and AS02V) or with liposomes (AS01B)," scientists in Rixensart, Belgium report.

"The fourth adjuvant was CpG oligonucleotide. High levels of antibodies were induced by all adjuvants, whereas cell-mediated immune responses, including cytolytic T cells and...


Source: Vaccine Weekly (2008-05-14)

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