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DNA Vaccines
Studies in the area of DNA vaccines reported from G.H. Tan and co-researchers
May 21st, 2008
"Eosinophils play a pivotal role in the generation of asthma inflammation. Interleukin (IL)-5 is the major activator of eosinophils," scientists in Hainan, People's Republic of China report. "We hypothesize that modulating IL5 activity could be an effective strategy for asthma therapy. In this study, we tested whether the plasmid encoding human IL-5 as a xenogeneic DNA vaccine could induce the production of autoantibodies, and be used for asthma treatment. A eukaryotic plasmid encoding the human IL-5 was constructed, and used as a DNA vaccine. A mouse model of asthma was established to observe its antiasthma activities. Eosinophils in tissue, blood and the...
Source: Vaccine Weekly (2008-05-21)
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