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Life Sciences
Researchers at Harvard University, Department of Medicine release new data on life sciences
May 21st, 2008
Scientists discuss in 'Pivotal advance: eosinophils mediate early alum adjuvant-elicited B cell priming and IgM production' new findings in life sciences. "Alum, aluminum-hydroxide-containing compounds, long used as adjuvants in human vaccinations, functions by ill-defined, immunostimulatory mechanisms. Antigen-free alum has been shown to act via a previously unidentified, splenic Gr1(+), IL-4-expressing myeloid cell population to stimulate early B cell priming," investigators in the United States report. "We demonstrate that the alum-elicited and -activated splenic myeloid cells are IL-4-expressing eosinophils that function to prime B cell responses. Eosinophils are...
Source: Vaccine Weekly (2008-05-21)
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