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Immunization
Researchers at University of Dusseldorf target immunization
May 28th, 2008
According to a study from Dusseldorf, Germany, "Prion diseases are transmissible neurodegenerative diseases of humans and animals. The prion agent consists of a misfolded protein, PrPsc (prion protein, scrapie form), of a glycosylphosphatidylinositol-anchored host protein, PrPC (PrP cellular form) of unknown function." "During prion replication, PrPsc induces host PrPC to adopt its pathogenic conformation. Some PrPsc may aggregate to microscopically visible, extracellular prion plaques that stain for amyloid. The development of antiprion vaccines presents some challenges. While there is strong self-tolerance to an endogenous antibody response to PrPC and PrPSe, highly...
Source: Vaccine Weekly (2008-05-28)
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