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Salmonellosis
Scientists at University of Rhode Island detail research in salmonellosis
May 28th, 2008
"Previously we showed that the tricarboxylic acid (TCA) cycle operates as a full cycle during Salmonella enterica serovar Typhimurium SR-11 peroral infection of BALB/c mice (M. Tchawa Yimga et al., Infect. Immun. 74:1130-1140, 2006)," scientists in the United States report. "The evidence was that a Delta sucCD mutant (succinyl coenzyme A [succinyl-CoA] synthetase), which prevents the conversion of succinyl-CoA to succinate, and a Delta sdhCDA mutant (succinate dehydrogenase), which blocks the conversion of succinate to fumarate, were both attenuated, whereas an SR-11 Delta aspA mutant (aspartase) and an SR-11 Delta frdABCD mutant (fumarate reductase), deficient in the...
Source: Vaccine Weekly (2008-05-28)
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