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Vaccine Weekly

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Immunization



New data from University of Buenos Aires illuminate research in immunization



May 28th, 2008

Fresh data on immunization are presented in the report 'Prime-boost immunization with cruzipain co-administered with MALP-2 triggers a protective immune response able to decrease parasite burden and tissue injury in an experimental Trypanosoma cruzi infection model.' "Cruzipain (Cz), a key Trypanosoma cruzi enzyme, is a main candidate antigen for vaccines against Chagas' disease. We evaluated a vaccination protocol based on intradermal priming with recombinant Cz and intranasal boosting with rCz co-administered with a derivative of the TLR2/6 agonist MALP-2," scientists in Junin, Argentina report.

"Vaccination triggered strong systemic and mucosal antibody...


Source: Vaccine Weekly (2008-05-28)

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