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Cancer Gene Therapy
Research in the area of cancer gene therapy reported from M.E. Mossoba and colleagues
May 28th, 2008
According to a study from Toronto, Canada, "Gene therapy strategies may accelerate the development of prophylactic immunotherapy against cancer. We synthesized a lentiviral (LV) vector encoding a kinase-deficient form of erbB2 ( erbB2tr) to transduce murine dendritic cells (DCs) efficiently." "Murine erbB2 models a clinically relevant tumor-associated self-antigen; its human homolog ( HER-2/neu) is overexpressed in breast cancer and in 80% of metastatic prostate cancers. Following one infection, similar to 47% of DCs overexpressed erbB2tr. To determine whether low doses of transduced DCs could protect mice from prostate cancer cells, we performed prime/boost...
Source: Vaccine Weekly (2008-05-28)
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