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Immunization
Research conducted at University of Siena, Medical Department has updated our knowledge about immunization
May 28th, 2008
According to recent research from Siena, Italy, "The effects of anticancer chemotherapy on antigen-specific cytotoxic T lymphocytes (CTLs) are mostly unknown. We tested the effects of cytotoxic drugs such as 5-fluorouracil, gemcitabine, and oxaliplatin on the functional activity of antigen-specific CTL cultures derived from the peripheral blood mononuclear cells of human donors." "We found that a biweekly drug-exposure of human HLA-A(*)02.01(+) CTLs derived from bulk cultures led to completely different effects if occurring early (day second) or late (day thirteenth) after the in vitro stimulations with the cognate peptides. In the first case, there was a significant...
Source: Vaccine Weekly (2008-05-28)
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