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University of Rochester Medical Center

Vaccine triggers immune response, prevents Alzheimer's

Published in Vaccine Weekly, June 4th, 2008

A vaccine created by University of Rochester Medical Center scientists prevents the development of Alzheimer's disease-like pathology in mice without causing inflammation or significant side effects.

Vaccinated mice generated an immune response to the protein known as amyloid-beta peptide, which accumulates in what are called "amyloid plaques" in brains of people with Alzheimer's. The vaccinated mice demonstrated normal learning skills and functioning memory in spite of being genetically designed to develop an aggressive form of the disease.

The Rochester scientists reported the findings in an article in the May issue of Molecular Therapy, the...

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