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Immunization
Research on immunization described by scientists at Leiden University
June 4th, 2008
New research, 'Superior induction of anti-tumor CTL immunity by extended peptide vaccines involves prolonged, DC-focused antigen presentation,' is the subject of a report. "Anti-tumor vaccines consisting of extended CTL peptides in combination with CpG-ODN were shown to be superior to those comprising minimal CTL epitopes and CpG-ODN, in that they elicit stronger effector CTL responses with greater tumoricidal potential. We now demonstrate that this improved performance is primarily due to the focusing of CTL epitope presentation onto activated DC in the inflamed lymph nodes draining the vaccination site," researchers in Leiden, Netherlands report. "In the case of...
Source: Vaccine Weekly (2008-06-04)
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