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Influenza Vaccines
Research from M. De Filette and colleagues provide new insights into influenza vaccines
June 4th, 2008
Fresh data on influenza are presented in the report 'An influenza a vaccine based on tetrameric ectodomain of matrix protein 2.' According to a study from Ghent, Belgium, "Matrix protein 2 (M2) of influenza A is a tetrameric type III membrane protein that functions as a proton-selective channel. The extracellular domain (M2e) has remained nearly invariable since the first human influenza strain was isolated in 1933." "By linking a modified form of the leucine zipper of the yeast transcription factor GCN4 to M2e, we obtained a recombinant tetrameric protein, M2e-tGCN4. This protein mimics the quaternary structure of the ectodomain of the natural M2 protein. M2e-tGCN4 was...
Source: Vaccine Weekly (2008-06-04)
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