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Tuberculosis Cell Biology
Reports from A.G. Pacheco and colleagues advance knowledge in tuberculosis cell biology
June 4th, 2008
Data detailed in 'IFNG +874T/A, IL10 -1082G/A and TNF -308G/A polymorphisms in association with tuberculosis susceptibility: a meta-analysis study' have been presented. "Susceptibility to infectious diseases is influenced by genetic background and efficient cellular immune activation is responsible for protection. In tuberculosis (TB), interferon-gamma (IFNgamma) is crucial to control intracellular growth of Mycobacterium tuberculosis while interleukin-10 (IL-10) has an antagonistic role," scientists in Rio de Janeiro, Brazil report. "Tumor necrosis factor (TNF) is a central mediator of granuloma formation and control of bacilli spread synergizing with IFNgamma...
Source: Vaccine Weekly (2008-06-04)
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