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Ebola Hemorrhagic Fever
Studies by A.L. Hartman and co-authors describe new findings in ebola hemorrhagic fever
June 4th, 2008
"Zaire ebolavirus causes a rapidly progressing hemorrhagic disease with high mortality. Identification of the viral virulence factors that contribute to the severity of disease induced by Ebola virus is critical for the design of therapeutics and vaccines against the disease," scientists writing in the Journal of Virology report. "Given the rapidity of disease progression, virus interaction with the innate immune system early in the course of infection likely plays an important role in determining the outcome of the disease. The Ebola virus VP35 protein inhibits the activation of IRF-3, a critical transcription factor for the induction of early antiviral...
Source: Vaccine Weekly (2008-06-04)
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