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Vaccines
Study results from Scripps Research Institute, Department of Immunology update understanding of vaccines
June 11th, 2008
Research findings, 'Vaccine adjuvants alter TCR-based selection thresholds,' are discussed in a new report. According to a study from the United States, "How T cell receptor (TCR) specificity evolves in vivo after protein vaccination is central to the development of helper T (Th) cell function. Most models of clonal selection in the Th cell compartment favor TCR affinity-based thresholds." "Here, we demonstrated that depot-forming vaccine adjuvants did not require Toll-like receptor (TLR) agonists to induce clonal dominance in antigen-specific Th cell responses. However, readily dispersible adjuvants using TLR-9 and TLR-4 agonists skewed TCR repertoire usage by...
Source: Vaccine Weekly (2008-06-11)
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