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Cancer Vaccines
Data on cancer vaccines detailed by M.E. Engelhorn and co-authors
June 11th, 2008
According to a study from the United States, "Successful approaches to tumor immunotherapy must overcome the physiological state of tolerance of the immune system to self-tumor antigens. Immunization with appropriate variants of syngeneic antigens can achieve this." "However, improvements in vaccine design are needed for efficient cancer immunotherapy. Here we explore nine different chimeric vaccine designs, in which the antigen of interest is expressed as an in-frame fusion with polypeptides that impact antigen processing or presentation. In DNA immunization experiments in mice, three of nine fusions elevated relevant CD8(+) T-cell responses and tumor protection...
Source: Vaccine Weekly (2008-06-11)
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